Smart nanobiomaterials and 3D technologies for active aging
Title of the research project
GIOTTO - Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies
Biomaterials, Bioengineering, Biology
GIOTTO project will develop technologies and smart materials aimed at the treatment of different types of bone fractures in people affected by osteoporosis. The innovative biomaterials will be able to stimulate bone regeneration and reduce bone resorption; moreover, the use of additive manufacturing technologies and 3D printing will pave the way to personalized therapeutic treatments.
Description of the research project
Bone is a dynamic tissue subject to a continuous remodelling process through a well-balanced coupling of new bone deposition (formation) by osteoblast cells and old bone removal (resorption) by osteoclast cells. When the balance between these two opposite processes is compromised, bone becomes porous and fragile. This pathology is called osteoporosis and affects elderly people: 1 woman over 3 and 1 man over 5 .
Giotto project will develop three types of devices specific for the treatment of different bone fractures.
- A three-dimensional bioresorbable scaffold to treat long bone fractures.
- A flexible composite material based on collagen fibres to be used for minimally invasive treatment of stable pelvic fractures.
- A radiopaque, bioresorbable and injectable cement to stabilise vertebral fractures
The three GIOTTO devices will incorporate both a biomolecule patented by one of the partners (NOVAICOS) able to inhibit osteoclast activity, thus slowing down bone resorption process, and bioactive nanomaterials containing therapeutic ions able to stimulate osteoblast activity, favouring a faster and effective healing of the fractured bones.
Impact on society
The proportion of elderly people in European societies is increasing fast and will have important social and economic effects in the coming years. In this context, the development of scientific and technological innovations aimed at allowing active and healthy aging is fundamental. The smart nano-biomaterials and 3D technologies developed in the framework of GIOTTO project will provide innovative and personalized solutions for people affected by osteoporosis, accelerating the possibility to come back to independence and to an active life thus contributing to mitigate the economic impact of this pathology on the health systems of European countries.
GIOTTO project is strongly interdisciplinary and will also contribute to the cross fertilization between universities and business sector, boosting the innovation of the European SME operating in the field of nanomaterials, medical devices and 3D technologies, attracting investments on highly specialised human capital.
Working group @Polito
At DISAT Department of Applied Science and Technology
Chiara Vitale Brovarone, Full professor, project coordinator
Sonia Fiorilli, Associate professor, WP leader
Remy Gauthier, Post-Doc researcher
Federica Banche Niclot, PhD student
Giorgia Montalbano, PhD student
Alessandra Bari, Post-Doc researcher
Giulia Molino, PhD student
Carlotta Pontremoli, PhD student
Stefania Sola, Administrative staff
National and International Partners
Università di Pisa, Centro Piaggio, Italy
Universiteit Maastricht, The Nederlands
Universidad Complutense de Madrid, Spain
Foundation for Research and Technology Hellas , Greece
University of Newcastle Upon Tyne, United Kingdom
Dublin City University, Irland
BE WARRANT, Belgium
CELLINK AB, Sweden
BIOMECH INNOVATIONS, Swizerland
Tecnología Navarra de Nanoproductos, Spain
GIOTTO project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 814410
- Budget: 5.660.096 euro
- Start date: 1/01/2019
- End date: 28/02/2023