Rapid, easy and efficient gene network reprogramming.

Title of the research project

GNRECC: Gene network rewiring by an engineered CRISPR-Cas12a variant

Scientific area 

Biochemistry, Bioengineering, Matter physics

Marie Skłodowska-Curie fellow

Carlo Cosimo Campa

Abstract  

The GNRECC project aims at creating new gene editing systems capable of inserting, deleting and modifying entire genetic programs in a quick, simple and effective way.

Description of the research project 

In the last ten years, the explosion of “-omics” sciences has allowed the generation of an enormous amount of data describing molecular changes underlying cellular functions. However, the role of these alterations remains unknown. This is mainly due to the lack of molecular tools able to modify entire genetic programs both quickly, easily and effectively. By combining both techniques inspired by statistical physics and bioengineering methods, the GNRECC project aims at developing new gene editing systems capable of reprogramming the cellular signaling pathways involved in tumor growth. Therefore, this project will pave the way for massive large-scale engineering of genetic networks.

Impact on fellow career and on society 

The GNRECC project will allow the researcher to demonstrate the potential of statistical physics techniques in bioengineering disciplines such as protein and genetic engineering. In addition, the creation of new and powerful gene editing systems will accelerate the development of both procedures and methodologies in the pharmaceutical and biomedicine industry as well as in emerging therapies aimed at treating both genetic diseases and human cancers.

Short CV of Marie Skłodowska-Curie fellow

Carlo Cosimo Campa received Industrial Biotechnology degree and a PhD in Biomedical Sciences and Oncology at the University of Turin. He has perfected his skills in bioengineering disciplines at the Swiss Federal Institute of Technology in Zurich. For his research activity, Carlo Cosimo Campa has received important international awards including those conferred by the Ministry of University and Research, the Italian Association for Cancer Research, the Eidgenössische Technische Hochschule Zürich and the European Commission.

Supervisor 

Andrea Pagnani, DISAT - Department of Applied Sciences and Technology

GNRECC project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 894574

  • Budget: 171,470 euro
  • Start date: 1/09/2020
  • End date: 28/02/2021